![]() ![]() When compared to sporadic neoplasms, hereditary pheochromocytomas typically present in younger individuals. In such cases, the catecholamine-secreting tumors are usually presented as bilateral adrenal pheochromocytomas (or paragangliomas). Causes of PheochromocytomaĪ majority of pheochromocytomas are sporadic nevertheless, in about 30 percent of patients this condition arises as part of a familial disorder. Pheochromocytoma can have exceptionally variable clinical presentation – from rare and escalating hypercatecholaminergic incidents, through rather stable hypertension, to dire and clinically malignant illness that can be complicated by hypertensive crisis, acute myocardial infarction, stroke, and a myriad of other emergent conditions. All these functional chromaffin tumors can result in substantial morbidity and mortality due to catecholamine over-secretion. Closely affiliated tumors of extra-adrenal paraganglia are also known as extra-adrenal pheochromocytomas. ![]() Pheochromocytomas are neural crest-derived tumors that produce catecholamines, such as epinephrine and norepinephrine, and arise mainly from the adrenal gland.
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